IEDB Analysis Resource

MHCI Weekly Benchmark results


Overall scores

Overall scores based on data sets submitted to the IED for the last at least 5 references. The overall scores in the SRCC and AUC columns are calculated using performance values for only SRCC or AUC respectively. In the overall column, both evaluation types are used.

Server Overall SRCC AUC
NetMHCpan 2.8 73 76 70
NetMHCpan 3.0 59 56 61
NetMHCpan 4.0 63 53 73
SMM 46 47 46
ANN 3.4 65 65 65
ANN 4.0 57 58 55
ARB 42 33 51
SMMPMBEC 55 59 51
IEDB Consensus 49 53 44
NetMHCcons 67 65 70
PickPocket 25 26 25
mhcflurry 1.2.0 84 88 81
DeepSeqPa 61 49 72
MultiPan - - -

Data set specific results

Detailed information for the evaluated data sets used in the calculation of the overall scores in the table above. Predictions from each participating server for the data sets listed below may be downloaded here

Datasets displayed in gray showed poor performance across all of the available predictors and are excluded from the overall ranking, pending further analysis.


IEDB
Reference
Allele Peptide
Length
Peptide
Count
Positive
Count
Measurement
type
NetMHCpan 2.8 NetMHCpan 3.0 NetMHCpan 4.0 SMM ANN 3.4 ANN 4.0 ARB SMMPMBEC IEDB Consensus NetMHCcons PickPocket mhcflurry 1.2.0 DeepSeqPa MultiPan
SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC
 1037895   HLA-A*02:01   9   12   8   ic50   0.692   0.719   0.497   0.656   0.587   0.719   0.657   0.688   0.692   0.750   0.643   0.656   0.643   0.719   0.699   0.688   0.677   0.703   0.664   0.719   0.503   0.562   0.790   0.781   0.636   0.781   -   - 
 1037895   HLA-A*02:01   10   11   6   ic50   0.691   0.733   0.700   0.833   0.573   0.767   0.355   0.567   0.555   0.700   0.573   0.700   0.536   0.767   0.355   0.567   -   -   0.636   0.733   0.296   0.550   -   -   -   -   -   - 
 1038020   HLA-A*02:01   9   14   6   t1/2   -0.123   0.417   -0.010   0.479   -0.010   0.479   -0.295   0.354   -0.200   0.396   -0.215   0.396   -0.163   0.458   -0.230   0.396   -0.303   0.354   -0.203   0.375   -0.183   0.417   -   -   -0.125   0.396   -   - 
 1038178   HLA-A*24:02   9   779   777   binary   0.081   0.965   0.078   0.945   0.069   0.896   0.082   0.970   0.078   0.945   0.081   0.961   0.085   0.986   0.085   0.985   0.082   0.966   0.080   0.958   0.074   0.924   0.116   0.974   0.085   0.984   -   - 
 1038478   HLA-A*02:01   9   25   12   binary   0.844   0.987   0.855   0.994   0.855   0.994   0.822   0.974   0.856   0.994   0.855   0.994   0.811   0.968   0.822   0.974   0.825   0.974   0.855   0.994   0.827   0.978   0.833   0.981   0.822   0.974   -   - 
 1038307   HLA-A*02:01   9   10   6   binary   0.782   0.958   0.711   0.917   0.782   0.958   0.711   0.917   0.711   0.917   0.711   0.917   0.569   0.833   0.711   0.917   -   -   0.711   0.917   0.711   0.917   0.782   0.958   0.711   0.917   -   -