IEDB Analysis Resource

MHCI Weekly Benchmark results


Overall scores

Overall scores based on data sets submitted to the IED for the last at least 5 references. The overall scores in the SRCC and AUC columns are calculated using performance values for only SRCC or AUC respectively. In the overall column, both evaluation types are used.

Server Overall SRCC AUC
NetMHCpan 2.8 55 52 57
NetMHCpan 3.0 59 62 55
NetMHCpan 4.0 68 73 64
SMM 74 69 78
ANN 3.4 61 61 62
ANN 4.0 64 58 70
ARB 38 28 49
SMMPMBEC 78 75 82
IEDB Consensus 68 63 74
NetMHCcons 60 59 60
PickPocket 53 48 58
mhcflurry 1.2.0 39 33 44
DeepSeqPa 61 51 71

Data set specific results

Detailed information for the evaluated data sets used in the calculation of the overall scores in the table above. Predictions from each participating server for the data sets listed below may be downloaded here

Datasets displayed in gray showed poor performance across all of the available predictors and are excluded from the overall ranking, pending further analysis.


IEDB
Reference
Allele Peptide
Length
Peptide
Count
Positive
Count
Measurement
type
NetMHCpan 2.8 NetMHCpan 3.0 NetMHCpan 4.0 SMM ANN 3.4 ANN 4.0 ARB SMMPMBEC IEDB Consensus NetMHCcons PickPocket mhcflurry 1.2.0 DeepSeqPa
SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC SRCC AUC
 1035424   H-2-Kb   9   13   8   binary   0.296   0.675   0.127   0.575   0.254   0.650   0.507   0.800   0.423   0.750   0.338   0.700   0.254   0.650   0.592   0.850   0.571   0.838   0.338   0.700   0.127   0.575   -0.085   0.450   -   - 
 1037140   HLA-A*02:01   9   12   3   ic50   0.595   0.852   0.634   0.852   0.683   0.889   0.630   0.926   0.557   0.815   0.592   0.889   0.588   0.926   0.630   0.926   0.582   0.889   0.616   0.852   0.599   0.889   -   -   0.606   0.963 
 1037261   HLA-B*07:02   9   52   50   binary   0.200   0.800   0.187   0.780   0.193   0.790   0.267   0.900   0.200   0.800   0.233   0.850   0.033   0.550   0.267   0.900   0.258   0.885   0.187   0.780   0.167   0.750   -   -   0.120   0.680 
 1037198   HLA-A*02:01   9   18   16   binary   0.545   1.000   0.545   1.000   0.545   1.000   0.545   1.000   0.546   1.000   0.545   1.000   0.545   1.000   0.545   1.000   0.547   1.000   0.545   1.000   0.545   1.000   0.545   1.000   0.545   1.000 
 1037014   HLA-A*02:01   9   16   11   binary   0.600   0.873   0.659   0.909   0.687   0.927   0.541   0.836   0.629   0.891   0.600   0.873   0.541   0.836   0.542   0.836   0.573   0.855   0.629   0.891   0.658   0.909   0.570   0.855   0.629   0.891